tert-Butyl carbazate → HCID 66618881, compound

Participants

Reaction Steps

5-Chloro-2-(5-isopropyl-4-methoxy-2-methylphenyl)pentanoic acid (6.2 g), tert-butyl carbazate (4.1 g) and N,N-diisopropylethylamine (10.8 mL) were dissolved in dichloromethane (120 mL). Bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride (7.9 g) was added under ice-cooling. After addition of the reagent, the mixture was brought back to room temperature and stirred overnight. The reaction solution was concentrated under reduced pressure. A sodium bicarbonate solution and tert-butyl methyl ether were added and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (6.1 g). The property values of the compound are as follows.

Provenance & Evidence