HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40633Generated: October 25, 2026
Diisopropylethylamine → (S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol
https://huagongshe.com/reaction/40633
Participants
| Role | Name | HCID | Charge |
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| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene | HCID 59686818 | — |
| Reactant | (S)-2-Methyl-5-oxiranylmethoxy-pyridine | HCID 59686824 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol | HCID 59686804 | — |
Reaction Steps
(S)-2-Methyl-5-oxiranylmethoxy-pyridine (13 mg, 0.077 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.189 mmol) were placed in a μW tube with ethanol (3 ml), DIPEA (15 μL, 0.086 mmol) and heated to 95° C. for 900 sec. The solvent was removed and the residue was purified via silica chromatography (30% Ethyl acetate/heptane) to yield the title compound as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530475B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-5d40740e23a44ef7bd32cf080e50788b |
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| Source note | uspto-grants-2013_09 |
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