Trifluoroacetic acid → HCID 66618862, compound

Participants

Reaction Steps

tert-Butyl N′-[5-bromo-3-(3-trifluoromethylphenyl)pentanoyl]hydrazinecarboxylate (1.6 g) was dissolved in methylene chloride (8 mL), and trifluoroacetic acid (10 mL) was added at 0° C. The mixture was stirred at room temperature for two hours and then concentrated under reduced pressure. The resulting oil was diluted with ethyl acetate, and then washed with 1 N sodium hydroxide aqueous solution and brine and dried over magnesium sulfate. The oil after concentration under reduced pressure (990 mg) was used directly for the next reaction as a crude product.

Provenance & Evidence