反应详情

温度

60 °C

4-Hydroxy-2-(2-trifluoromethylphenyl) butyronitrile (2.6 g) was dissolved in pyridine (10 mL). Thionyl chloride (2.1 mL) was carefully added and the mixture was heated with stirring at 60° C. for four hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (1.3 g). The property values of the compound are as follows.

1. temperaturethe mixture was heated
2. extractionfollowed by extraction with ethyl acetate
3. washThe resulting organic layer was washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customThe drying agent was separated by filtration
6. concentrationthe organic layer was concentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography