Ethanol → Ethyl 4-ethoxycarbonimidoyl-4-(2-trifluoromethylphenyl)butanoate hydrochloride

HRID 406362Notes

Reaction equation

HRID 406362 reaction equation
[C:1]([CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([F:19])([F:18])[F:17])[CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7])#[N:2].[C:20]([Cl:23])(=[O:22])[CH3:21].[CH2:24](O)C>>[ClH:23].[CH2:20]([O:22][C:1]([CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([F:18])([F:17])[F:19])[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:24])=[O:7])=[NH:2])[CH3:21]

Participants

4

Reactant 3

HCID 702EthanolHCID 6367Acetyl chlorideHCID 66618793Methyl 4-cyano-4-(2-trifluoromethylphenyl)butanoate

Product 1

HCID 66628906Ethyl 4-ethoxycarbonimidoyl-4-(2-trifluoromethylphenyl)butanoate hydrochloride

Procedure

Methyl 4-cyano-4-(2-trifluoromethylphenyl)butanoate (200 mg) was dissolved in ethanol (1.03 mL), and acetyl chloride (838 μl) was added at 0° C. The mixture was heated to room temperature and the reaction was initiated. After stirring for 24 hours, concentration under reduced pressure gave a crude product of the title compound as an oil (300 mg).

Workup

  1. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-2c988077b71f41e39b000cb2a63e958e
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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