Tetrabutylammonium Fluoride → HCID 66618792, compound

Participants

Reaction Steps

5-(tert-Butyldiphenylsilanylsilanyloxy)-3-(4-trifluoromethylphenyl)pentanenitrile (600 mg) was dissolved in tetrahydrofuran (6 mL), and tetrabutylammonium fluoride (1.5 mL) was added at room temperature. After two hours, the mixture was partitioned with water and ethyl acetate. The organic layer was washed with brine and then dried over magnesium sulfate. Concentration under reduced pressure gave an oil. The oil was purified by silica gel column chromatography (mobile phase:ethyl acetate/heptane=70%) to obtain the title compound (306 mg).

Provenance & Evidence