反应详情

4-Carbamoyl-3-(2-trifluoromethylphenyl)butanoic acid (646 mg) was dissolved in methylene chloride (32 mL), and a diborane-tetrahydrofuran solution (7.12 mL) was added at 0° C. After stirring at room temperature for two hours, the reaction solution was cooled to 0° C. The reaction was terminated with 1 N hydrochloric acid, followed by dilution with ethyl acetate. The organic layer was washed with 1 N sodium hydroxide and brine and dried over magnesium sulfate. Concentration under reduced pressure gave a crude product (388 mg) which was used for the next reaction without purification.

1. temperaturethe reaction solution was cooled to 0° C
2. customThe reaction was terminated with 1 N hydrochloric acid
3. washThe organic layer was washed with 1 N sodium hydroxide and brine
4. dry with materialdried over magnesium sulfate
5. concentrationConcentration under reduced pressure