Benzoic acid, 3-nitro-4-(1-piperidinyl)-, methyl ester → methyl 3-amino-4-piperidin-1-ylbenzoate

Participants

Reaction Steps

Using 10% palladium carbon cartridge, a solution of methyl 3-nitro-4-(piperidin-1-yl)benzoate (3.07 g) in methanol (50 ml) was pumped through the H-Cube™ reactor (ThalesNano Inc.). After all the reaction mixture had passed through the H-Cube™ reactor, the reaction mixture was concentrated under reduced pressure. The residue was purified by NH-silica gel column chromatography to obtain a title compound (2.32 g).

Provenance & Evidence