Borane;tetrahydrofuran → HCID 66780431, compound

Participants

Reaction Steps

Borane-THF complex (1.0M solution in THF, 13.7 ml) was added under ice-cooling to a solution of methyl 2-chloro-4-[cyclopropylmethyl(2,2,2-trifluoroacetyl)amino]benzoate (500 mg) in dichloromethane (10 ml). The reaction mixture was then refluxed overnight. After cooling to room temperature, the mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate.

Provenance & Evidence