Acetic Acid → HCID 66778551, compound

Participants

Reaction Steps

To a solution of 7-benzyl-8-biphenyl-3-yl-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine (541 mg) and acetic acid (1.32 ml) in methanol (52 ml) was added 20% palladium hydroxide (743 mg) and the reaction mixture was stirred at room temperature in a hydrogen atmosphere for 4 days. After the reaction atmosphere was replaced with nitrogen, ethyl acetate was added to the reaction mixture. The catalyst was removed by filtration by Celite. The filtrate was concentrated under reduced pressure and the residue was purified by NH silica gel column chromatography to obtain the title compound (45 mg) and the raw material. (291 mg)

Provenance & Evidence