HCID 67405098, compound → HCID 67405401, compound

HRID 406405Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:19][CH:20]3[CH2:38][CH:37]4[N:22]([C:23](=[O:43])[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]=[CH:31][CH:32]5[C:34]([C:40]([OH:42])=O)([NH:35][C:36]4=[O:39])[CH2:33]5)[CH2:21]3)=[CH:8][C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10]2)=[CH:5][CH:4]=1.COC1C=C2C(C(OC3CC4N(C(=O)OCCCCC=CC5C(C([NH:84][S:85]([CH:88]6[CH2:90][CH2:89]6)(=[O:87])=[O:86])=O)(NC4=O)C5)C3)=CC(C3C=CC=CC=3)=N2)=CC=1>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:19][CH:20]3[CH2:38][CH:37]4[N:22]([C:23](=[O:43])[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]=[CH:31][CH:32]5[C:34]([C:40]([NH:84][S:85]([CH:88]6[CH2:90][CH2:89]6)(=[O:87])=[O:86])=[O:42])([NH:35][C:36]4=[O:39])[CH2:33]5)[CH2:21]3)=[CH:8][C:9]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[N:10]2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 67405098HCID 67405098, compound

HCID 67405250HCID 67405250, compound

Product 1

HCID 67405401HCID 67405401, compound

Procedure

The title compound 25 was synthesized from compound 24 following the same procedure described for the synthesis of N-[17-(7-methoxy-2-phenylquinolin-4-yloxy)-2,14-dioxo-3,15-diaza-13-oxatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide (23): m/z=689 (M+H)+.

Sources & evidence

ORD record: ord-093193350af64a7bb0467497c343fb99
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754105B2

Reaction notes

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