Formamide → HCID 178487732, compound

HRID 406407Notes

Reaction equation

HRID 406407 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([NH:8][C:9]2[C:17]([CH3:18])=[C:16]([O:19][CH3:20])[CH:15]=[CH:14][C:10]=2[C:11](O)=[O:12])=O)=[CH:4][CH:3]=1.C([NH2:25])=O>>[F:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]2[N:25]=[C:11]([OH:12])[C:10]3[C:9](=[C:17]([CH3:18])[C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[N:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 591654752-(4-Fluorobenzamido)-4-methoxy-3-methylbenzoic acid

Product 1

HCID 178487732HCID 178487732, compoundYield 83%

Procedure

2-(4-Fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid (29) (830 mg, 2.7 mmol) was heated to 150° C. in formamide (20 ml) for 4 h. The excess formamide was removed by distillation. Water was added and the precipitated product was filtered of to give pure title compound (642 mg, 83%).

Workup

  1. customThe excess formamide was removed by distillation
  2. additionWater was added
  3. filtrationthe precipitated product was filtered of

Sources & evidence

ORD record
ord-4abe3c0551164477a2669d38d47ce5f3
Source dataset
uspto-grants-2014_06
Patent number
US08754105B2

Reaction notes

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