反应详情

温度

80 °C

A suspension of 5-bromo-3-nitro-2-hydrazinopyridine (2.0 g, 8.58 mmol) in trimethylorthoacetate (20 mL) was heated at 80° C. for 20 h. After cooling, the solvent was distilled off, the residue was dissolved in ethyl acetate (200 mL), washed with water, brine, dried over sodium sulphate and concentrated to provide the product 6-bromo-3-methyl-8-nitro-[1,2,4]triazolo[4,3-a]pyridine.

1. temperatureAfter cooling
2. distillationthe solvent was distilled off
3. dissolutionthe residue was dissolved in ethyl acetate (200 mL)
4. washwashed with water, brine
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated