反应详情

4-(3-Chloro-propoxy)-2-methyl-1H-indole (0.16 g, 0.72 mmol), Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (0.1 g, 0.38 mmol), K2CO3 (72 mg, 0.52 mmol), acetonitrile (30 mL) were placed in a round bottom flask and refluxed overnight. To the reaction mixture were then added ethyl acetate (100 mL) and water (100 mL) and the resulting mixture stirred for 30 minutes. The organic layer was separated and dried with magnesium sulfate, filtered and the solvent evaporated under reduced pressure to yield a crude solid. The crude solid was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate] to yield the title compound as a residue.

1. temperaturerefluxed overnight
2. customThe organic layer was separated
3. dry with materialdried with magnesium sulfate
4. filtrationfiltered
5. customthe solvent evaporated under reduced pressure
6. customto yield a crude solid
7. customThe crude solid was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate]