HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,2-Difluoro-3-methoxypropionate → N'-(5-bromopyridin-2-yl)-2,2-difluoro-3-methoxypropanehydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,2-Difluoro-3-methoxypropionate | HCID 2769543 | — |
| Reactant | 5-Bromo-2-hydrazinopyridine | HCID 11535699 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N'-(5-bromopyridin-2-yl)-2,2-difluoro-3-methoxypropanehydrazide | HCID 66849873 | — |
Reaction Steps
(5-bromo-2-hydrazinylpyridine (1.83 g, 9.73 mmol) and methyl 2,2-difluoro-3-methoxypropanoate (1.00 g, 6.49 mmol) were refluxed in toluene (35 mL) overnight. The reaction mixture was concentrated and purified by chromatography (EtOAc: hexanes=1:4) to give N′-(5-bromopyridin-2-yl)-2,2-difluoro-3-methoxypropanehydrazide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754103B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-2a7604a821444d9ba2a45a869634ef88 |
| Source note | uspto-grants-2014_06 |