Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 406444생성일: 2026년 10월 25일
1-Ethynyl-4-(trifluoromethyl)benzene → 3-(1,1-Difluoro-2-methoxyethyl)-6-((4-(trifluoromethyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-a]pyridine
https://huagongshe.com/reaction/406444
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethynyl-4-(trifluoromethyl)benzene | HCID 4348295 | — |
| 반응물 | 6-Bromo-3-(1,1-difluoro-2-methoxyethyl)-[1,2,4]triazolo[4,3-a]pyridine | HCID 58118956 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(1,1-Difluoro-2-methoxyethyl)-6-((4-(trifluoromethyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-a]pyridine | HCID 50908330 | — |
반응 단계
To a stirred solution of 6-bromo-3-(1,1-difluoro-2-methoxyethyl)-[1,2,4]triazolo[4,3-a]pyridine (46 mg, 0.16 mmol) in THF (5 mL) was added catalytic amount of dichlorobis(triphenylphosphine) palladium(II) (11 mg) and copper(I) iodide (3 mg), followed by 1-ethynyl-4-(trifluoromethyl)benzene (41 mg, 0.24 mmol). The resulting mixture was flushed with N2 and Et3N (2 mL) was added. The reaction mixture was stirred at 70° C. overnight and purified by prep-TLC (EtOAc: hexanes=2:3) followed by HPLC to give 3-(1,1-difluoro-2-methoxyethyl)-6-((4-(trifluoromethyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-a]pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08754103B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-b90f0c8d8a514419babce827e758a1e5 |
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| 출처 메모 | uspto-grants-2014_06 |
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