反应详情

1-(2-Methyl-1H-indol-4-yloxy)-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol (0.05 g, 0.107 mmol), 10% Pd/C (0.05 g), methanol (15 mL) were placed in an hydrogenation bottle under H2 atmosphere (60 psi) and shaken overnight. The resulting mixture was filtered and the solvent evaporated under reduced pressure to yield a crude solid. The crude solid was purified with flash chromatography [20% Ethyl acetate/heptane] to yield the title compound as a residue.

1. filtrationThe resulting mixture was filtered
2. customthe solvent evaporated under reduced pressure
3. customto yield a crude solid
4. customThe crude solid was purified with flash chromatography [20% Ethyl acetate/heptane]