Diisopropylethylamine → 1-(9-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-3-(quinolin-5-yloxy)-propan-2-ol

Beteiligte Stoffe

Reaktionsschritte

5-Oxiranylmethoxy-quinoline (13 mg, 0.065 mmol), 7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.042 mmol), DIPEA (0.1 mL, 0.55 mmol) and ethanol (2 mL) were μW for 900 sec at 130° C. in a μW reaction tube. The solvent was evaporated in vacuo to yield a crude solid that was purified with flash chromatography gradient [30% EtOAc/heptane to 100% EtOAc] to yield the title compound as its free base, as a residue.

Herkunft & Nachweise