HCID 59764941, compound → HCID 86621725, compound

Participants

Reaction Steps

To [(2S,3R)-1-(2-benzyloxycarbonylamino-acetyl)-2-methyl-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (example #14) (0.75 g, 1.916 mmol) in ethanol (101 mL) was added 10% palladium on carbon (0.020 g, 0.19 mmol). The flask was fitted with a hydrogen balloon and hydrogenated for about 16 h. The reaction mixture was filtered, washing with EtOH. The filtrate was concentrated under reduced pressure to afford tert-butyl (2S,3R)-1-(2-aminoacetyl)-2-methylpyrrolidin-3-ylcarbamate (0.50 g, 1.9 mmol). RP-HPLC (Table 1, Method d) Rt 3.05; m/z: (M+H)+ 258.

Provenance & Evidence