4,6,7-Trichloroquinazoline → HCID 86621726, compound

HRID 406507Notes

Reaction equation

HRID 406507 reaction equation
[NH2:1][CH2:2][C:3]([N:5]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C@@H:6]1[CH3:18])=[O:4].Cl[C:20]1[C:29]2[C:24](=[CH:25][C:26]([Cl:31])=[C:27]([Cl:30])[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[Cl:30][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][C:26]=1[Cl:31])[N:23]=[CH:22][N:21]=[C:20]2[NH:1][CH2:2][C:3]([N:5]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:16])[CH3:15])[C@@H:6]1[CH3:18])=[O:4]

Participants

3

Reactant 2

HCID 534260304,6,7-TrichloroquinazolineHCID 86621725HCID 86621725, compound

Product 1

HCID 86621726HCID 86621726, compound

Procedure

tert-Butyl (2S,3R)-1-(2-(6,7-dichloroquinazolin-4-ylamino)acetyl)-2-methylpyrrolidin-3-ylcarbamate was synthesized from tert-butyl (2S,3R)-1-(2-aminoacetyl)-2-methylpyrrolidin-3-ylcarbamate and 4,6,7-trichloroquinazoline using general procedure M. RP-HPLC (Table 1, Method d) Rt 5.67; m/z: (M+H)+ 454.

Sources & evidence

ORD record
ord-0d3c2104249e400487fcd209105f4167
Source dataset
uspto-grants-2014_06
Patent number
US08754107B2

Reaction notes

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