Methanol → Brt3qrq73F

HRID 406522Notes

Reaction equation

HRID 406522 reaction equation
I[C:2]1[CH:3]=[C:4]2[CH2:19][C@@:9]3([C:17]4[C:12](=[N:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[CH2:8][C:5]2=[N:6][CH:7]=1.[C:20]([O-:23])(=[O:22])C.[Na+].[CH3:25]O>O.ClCCl.[Pd+2].ClC1C=C[C-](P(C2C=CC=CC=2)C2C=CC=CC=2)C=1Cl.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2]>[O:18]=[C:10]1[NH:11][C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:17]2[C@@:9]21[CH2:8][C:5]1=[N:6][CH:7]=[C:2]([C:20]([O:23][CH3:25])=[O:22])[CH:3]=[C:4]1[CH2:19]2

Participants

6

Reactant 3

HCID 887MethanolHCID 517045Sodium AcetateHCID 58118681(6S)-3-Iodo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2' (1'H)-one

Product 1

HCID 69098169Brt3qrq73F

Reagents, catalysts & solvents 2

HCID 178478475HCID 178478475, compoundCatalystHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A solution of (6S)-3-iodo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one (51.0 g, 140 mmol), sodium acetate (23.0 g, 281 mmol) and dichloro 1,1′-bis(diphenylphosphino)ferrocene palladium(II) dichloromethane adduct (2.9 g, 3.5 mmol) in MeOH (560 mL) was pressurized to 120 psi of CO at 23° C. and then heated at 80° C. for 12 h with stirring. The reaction mixture was diluted with water (1 L), and the precipitate collected by filtration, washed with water, and dried under nitrogen atmosphere to give the title compound, which was used without further purification. MS: m/z=296.1 (M+1).

Workup

  1. customwas pressurized to 120 psi of CO at 23° C.
  2. filtrationthe precipitate collected by filtration
  3. washwashed with water
  4. customdried under nitrogen atmosphere

Sources & evidence

ORD record
ord-736c3917d7544d89be84794394f87ebe
Source dataset
uspto-grants-2014_06
Patent number
US08754096B2

Reaction notes

Loading…