HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 1-Bromo-4-(1-isocyanatoethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Bromo-4-(1-isocyanatoethyl)benzene | HCID 610983 | 63% |
Reaction Steps
To a solution of (S)-1-(4-bromophenyl)ethanamine (240 g, 1.2 mol) in methylene chloride (3 L) and satd aq NaHCO3 (3 L) solution was added triphosgene (118 g, 0.396 mol) at 0° C. The mixture was stirred for 15 min. The organic phase was separated, dried over Na2SO4 and concentrated to give 1-bromo-4-(1-isocyanato-ethyl)-benzene (170 g, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754076B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-0e080dc9898b4d0d8a595534aa9fac47 |
| Source note | uspto-grants-2014_06 |