4-Iodo-1-methylpyridin-2(1H)-one → HCID 59635717, compound

HRID 406658Notes

Reaction equation

HRID 406658 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@:8]2([CH2:32][C:33]([OH:36])([CH3:35])[CH3:34])[O:13][C:12](=[O:14])[N:11]([C@H:15]([C:17]3[CH:22]=[CH:21][C:20](B4OC(C)(C)C(C)(C)O4)=[CH:19][CH:18]=3)[CH3:16])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.I[C:38]1[CH:43]=[CH:42][N:41]([CH3:44])[C:40](=[O:45])[CH:39]=1>>[F:1][C:2]1[CH:3]=[C:4]([C@:8]2([CH2:32][C:33]([OH:36])([CH3:34])[CH3:35])[O:13][C:12](=[O:14])[N:11]([C@H:15]([C:17]3[CH:22]=[CH:21][C:20]([C:38]4[CH:43]=[CH:42][N:41]([CH3:44])[C:40](=[O:45])[CH:39]=4)=[CH:19][CH:18]=3)[CH3:16])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 534080094-Iodo-1-methylpyridin-2(1H)-oneHCID 66736273HCID 66736273, compound

Product 1

HCID 59635717HCID 59635717, compound

Procedure

The title compound was prepared from (S)-6-(3-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 4-iodo-1-methylpyridin-2(1H)-one following a procedure analogous to that described in Example 23 Step 9. LC-MS Method 2 tR=1.57 min, m/z=501, 479, 421.

Sources & evidence

ORD record
ord-2f7255c6ec844db797104b8776223225
Source dataset
uspto-grants-2014_06
Patent number
US08754076B2

Reaction notes

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