5-Bromo-1-methylpyridin-2(1H)-one → (6S)-6-(2-Hydroxyethyl)-3-[(1S)-1-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]propyl]-6-phenyl-1,3-oxazinan-2-one

Participants

Reaction Steps

The title compound was prepared from (S)-3-((S)-1-(4-bromophenyl)propyl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one following a procedure analogous to that described in Example 18 using 5-bromo-1-methylpyridin-2(1H)-one in Step 2. LC-MS Method 2 tR=1.627 min, m/z=447.1; 1H NMR (CDCl3) 1.06 (m, 3H), 1.87-2.06 (m, 2H), 2.11-2.28 (m, 2H), 2.33 (m, 3H), 2.96 (m, 1H), 3.53 (m, 1H), 3.62 (s, 3H), 3.78 (m, 1H), 5.48 (m, 1H), 6.69 (m, 1H),7.03 (m, 2H), 7.14 (m, 2H), 7.21-7.38 (m, 4H), 7.41 (s, 1H), 7.56 (m, 1H).

Provenance & Evidence