Isobutylene oxide → 4-Bromo-1-(2-hydroxy-2-methylpropyl)-2(1H)-pyridinone

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-1H-pyridin-2-one (0.25 g), 2,2-dimethyl-oxirane (0.26 mL), and potassium carbonate (0.40 g) in dimethylformamide (2.5 mL) was stirred under microwave irradiation at 120° C. for 30 min. After cooling to ambient temperature, the mixture was concentrated and purified by HPLC on reversed phase (acetonitrile/water) to afford the title compound. Yield: 0.34 g (96% of theory); Mass spectrum (ESI+): m/z=246/248 (Br) [m+H]+.

Provenance & Evidence