5-Aminopyrazine-2-carbonitrile → 5-(8-Bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile

Participants

Reaction Steps

The title compound was prepared using methods analogous to those described in Synthesis 5-1 using 2-amino-5-cyanopyrazine in place of (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile and 8-bromoisoquinolin-3-yl trifluoromethanesulfonate in place of 3,8-dichloroisoquinoline. 1H NMR (DMSO, 400 MHz) δ 11.30 (br s, 1H), 9.40 (s, H), 8.95 (s, H), 8.80 (s, H), 8.60 (s, H), 8.05 (d, 1H, J=8.5 Hz), 7.95 (d, 1H, J=7.5 Hz), 7.75 (dd, 1H, J=8.5 Hz, 7.5 Hz). LC-MS (2) Rt=3.21 min, m/z (ESI+) 326 & 328 (MH+).

Provenance & Evidence