5-Aminopyrazine-2-carbonitrile → HCID 44204555, compound

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The title compound was prepared using methods analogous to those described in Synthesis 5-1 using 2-amino-5-cyanopyrazine in place of (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile, and using 5-bromo-8-chloroisoquinolin-3-yl trifluoromethanesulfonate in place of 3,8-dichloroisoquinoline. 5-Bromo-8-chloroisoquinolin-3-yl trifluoromethanesulfonate was prepared using methods analogous to those described in Synthesis 11-1 for 8-bromoisoquinolin-3-yl trifluoromethanesulfonate. 1H NMR (DMSO, 400 MHz) δ 11.3 (br s, 1H), 9.42 (s, 1H, J=0.8 Hz), 8.85 (d, 1H, J=1.3 Hz), 8.81 (d, 1H, J=1.3 Hz), 8.79 (d, 1H, J=0.8 Hz), 8.07 (d, 1H, J=8.1 Hz), 7.58 (d, 1H, J=8.1 Hz). LCMS (2) Rt=3.58 min; m/z (ESI+) 360 & 362 (M+H).

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