2-Morpholinoethylamine → 5-(8-(2-Morpholinoethylamino)isoquinolin-3-ylamino)pyrazine-2-carbonitrile

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared using methods analogous to those described in Synthesis 5-1, replacing 3,8-dichloroisoquinoline with 5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile and replacing (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile with N-(2-aminoethyl)morpholine, and conducting the reaction at 140° C.

Herkunft & Nachweise