(E)-3-(3-Chloro-benzo[b]thiophen-2-yl)-acrylic acid methyl ester → 3-(3-Chloro-benzo[b]thiophen-2-yl)-propionic acid methyl ester

Participants

Reaction Steps

A solution of 3.60 g (14.6 mmol) of 14 in 50 mL THF was treated with Wilkinson's catalyst (3.35 g, 3.62 mmol). The mixture was stirred under 1 atm H2 for 18 h and then was filtered through celite. The solvent was evaporated and the residue purified by flash chromatography on silica gel (0-2% ethyl acetate/hexane) to give 3.63 g (14.3 mmol, 99%) of the saturated ester (15).

Provenance & Evidence