HCID 66899822, compound → HCID 53235632, compound

Participants

Reaction Steps

To the yellow colored suspension prepared by suspending the compound obtained in Step 4 (19.9 g, 65 mmol) in methanol (200 ml), 10% palladium on carbon (4.0 g) was added. The resulting mixture was subjected to vacuum outgassing and stirred at r.t., for 2 hrs in the flask connected with hydrogen bollum. The resulting mixture was filtered through celite 545 under redued pressure to remove the palladium on carbon. The filterate was concentrated under reduced pressure (reflux condenser, 10 torr, 40). The resulting pale brown colored residue was dissolved in isopropylalcohol (140 ml) and refluxed to dissolve completely. The resulting solution was stood at 0 for 2 hrs to cool, stirred for 30 min and filtered off under redued pressure. The resulting ivory crystalline solid was dried in vacuo to obtain the title compound (15.8 g, 88%).

Provenance & Evidence