Dimethylformamide → HCID 67309452, compound

Participants

Reaction Steps

To a mixture of 5-(4-chlorophenyl)-2-(dimethylamino-methyleneamino)-2H-pyrazole-3-carboxylic acid (Example 18A, 0.175 g, 0.59 mmol) and DMF (2 mL) was added HOBT (0.039 g, 0.3 mmol), EDCI HCl (0.33 g, 1.7 mmol) and DIPEA (0.15 g, 1.18 mmol). The resulting mixture was stirred at room temperature for 15 min. Example 18C was then added and the mixture was stirred at room temperature overnight. Reaction mass was quenched into water, solid obtained was filtered and washed with water. Pale brown solid (Example 18D, 0.1 g, 37% yield) obtained was taken to the next step without purification. LC-MS, [M+H]+=467.

Provenance & Evidence