4-Morpholinecarbonyl chloride → N-[3-(7-{1-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

Participants

Role	Name	HCID	Charge
Reactant	4-Morpholinecarbonyl chloride	HCID 84810	—
Reactant	N-{3-[7-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea	HCID 67980436	—
Product	N-[3-(7-{1-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 57387891	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 30 (Step 6) starting from N-{3-[7-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N′-(2,2,2-trifluoroethyl)urea and morpholine-4-carbonyl chloride (Aldrich, Cat. No. 348295). LCMS (M+H)+: m/z=598.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08754114B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-ae5168c316824c339855ee79c01a5ab8
Source note	uspto-grants-2014_06