HRID407013

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2760493

3-isocyanatopyridine

C6H4N2O

HCID67980436

未命名化合物

PRODUCTS

产物

HCID57387892

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 30 (Step 6) starting from N-{3-[7-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N′-(2,2,2-trifluoroethyl)urea and 3-isocyanatopyridine (Oakwood, Cat. No. 022077). LCMS (M+H)+: m/z=605.3.

WORKUP

后处理

customThis compound was prepared
customthose described for the synthesis of Example 30 (Step 6)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-81aed308e4f941eba260d2f88a891e49
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08754114B2
来源说明: uspto-grants-2014_06

反应SMILES

[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[N:16][N:15]4[C:18]([C:21]5[CH:22]=[C:23]([NH:27][C:28]([NH:30][CH2:31][C:32]([F:35])([F:34])[F:33])=[O:29])[CH:24]=[CH:25][CH:26]=5)=[CH:19][N:20]=[C:14]4[CH:13]=3)[CH:9]=[N:8]2)[CH2:3][CH2:2]1.[N:36]([C:39]1[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=1)=[C:37]=[O:38]>>[N:41]1[CH:42]=[CH:43][CH:44]=[C:39]([NH:36][C:37]([N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[CH:11]=[C:10]([C:12]4[CH:17]=[N:16][N:15]5[C:18]([C:21]6[CH:26]=[CH:25][CH:24]=[C:23]([NH:27][C:28]([NH:30][CH2:31][C:32]([F:33])([F:35])[F:34])=[O:29])[CH:22]=6)=[CH:19][N:20]=[C:14]5[CH:13]=4)[CH:9]=[N:8]3)[CH2:3][CH2:2]2)=[O:38])[CH:40]=1