Methoxyacetyl chloride → N-[3-(7-{1-[3-(Cyanomethyl)-1-(methoxyacetyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

Participants

Role	Name	HCID	Charge
Reactant	Methoxyacetyl chloride	HCID 96623	—
Reactant	N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 67980375	—
Product	N-[3-(7-{1-[3-(Cyanomethyl)-1-(methoxyacetyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 57385639	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 73, Step 4 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and methoxyacetyl chloride. LCMS (M+H)+: m/z=568.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08754114B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-0446b6da13df4237b890a5b3caedd702
Source note	uspto-grants-2014_06