2-(Dimethylamino)acetyl chloride hydrochloride → HCID 57385889, compound

HRID 407053Notes

Reaction equation

HRID 407053 reaction equation
[C:1]([CH2:3][C:4]1([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[N:17][N:16]4[C:19]([C:22]5[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:36])([F:35])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=5)=[CH:20][N:21]=[C:15]4[CH:14]=3)[CH:10]=[N:9]2)[CH2:7][NH:6][CH2:5]1)#[N:2].Cl.[CH3:38][N:39]([CH2:41][C:42](Cl)=[O:43])[CH3:40]>>[C:1]([CH2:3][C:4]1([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[N:17][N:16]4[C:19]([C:22]5[CH:23]=[C:24]([NH:28][C:29]([NH:31][CH2:32][C:33]([F:35])([F:36])[F:34])=[O:30])[CH:25]=[CH:26][CH:27]=5)=[CH:20][N:21]=[C:15]4[CH:14]=3)[CH:10]=[N:9]2)[CH2:5][N:6]([C:42](=[O:43])[CH2:41][N:39]([CH3:40])[CH3:38])[CH2:7]1)#[N:2]

Participants

3

Reactant 2

HCID 139949912-(Dimethylamino)acetyl chloride hydrochlorideHCID 67980375N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

Product 1

HCID 57385889HCID 57385889, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 73, Step 4 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and dimethylaminoacetyl chloride hydrochloride (Lancaster and Cat. No. L18475). LCMS (M+H)+: m/z=581.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-68c58f9d653443729560659bbc94e837
Source dataset
uspto-grants-2014_06
Patent number
US08754114B2

Reaction notes

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