2-(Oxolan-2-yl)acetic acid → N-[3-(7-{1-[3-(Cyanomethyl)-1-(tetrahydrofuran-2-ylacetyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

참여 물질

역할	이름	HCID	투입량
반응물	2-(Oxolan-2-yl)acetic acid	HCID 228726	—
반응물	N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 67980375	—
생성물	N-[3-(7-{1-[3-(Cyanomethyl)-1-(tetrahydrofuran-2-ylacetyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 57386162	—

반응 단계

This compound was prepared by using procedures analogous to those described for the synthesis of Example 77 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and tetrahydrofuran-2-ylacetic acid (Matrix Scitific, cat. No. 020454). LCMS (M+H)+: m/z=608.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08754114B2
출처 데이터셋	uspto-grants-2014_06
ORD ID	ord-84eb081e971948939ce4f78664fd6d30
출처 메모	uspto-grants-2014_06