3-Phenylprop-2-enenitrile → N-(3-{7-[1-(2-Cyano-1-phenylethyl)-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl}phenyl)-N'-(2,2,2-trifluoroethyl)urea

Participants

Role	Name	HCID	Charge
Reactant	3-Phenylprop-2-enenitrile	HCID 74667	—
Reactant	N-[3-(7-{-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea	HCID 67980550	—
Product	N-(3-{7-[1-(2-Cyano-1-phenylethyl)-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl}phenyl)-N'-(2,2,2-trifluoroethyl)urea	HCID 57386681	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 89, Step 2 starting from N-{3-[7-(1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N′-(2,2,2-trifluoroethyl)urea and cinnamonitrile. LCMS (M+H)+: m/z=531.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08754114B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-57c460ce7df54a53bba37dabef9c1f16
Source note	uspto-grants-2014_06