Ethyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate → Ethyl 2-(4-(6-oxo-1,6-dihydropyridazin-4-yl)phenyl)propanoate

HRID 407084Notes

Reaction equation

HRID 407084 reaction equation
Cl[C:2]1[CH2:3][C:4](=[O:8])[N:5]=[N:6][CH:7]=1.CC1(C)C(C)(C)OB([C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:19][CH:18]=2)O1>>[O:8]=[C:4]1[NH:5][N:6]=[CH:7][C:2]([C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:19][CH:18]=2)=[CH:3]1

Participants

3

Reactant 2

HCID 58539349Ethyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoateHCID 679801625-chloropyridazin-3(4H)-one

Product 1

HCID 67980170Ethyl 2-(4-(6-oxo-1,6-dihydropyridazin-4-yl)phenyl)propanoate

Procedure

This compound was prepared by using procedure analogous to those described for the synthesis of Example 94, Step 1 starting from 5-chloropyridazin-3(4H)-one and ethyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate (Example 14, Step 2). LCMS (M+H)+: m/z=273.1

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fb7ca628a7744b2c8bd0b8438a8f216f
Source dataset
uspto-grants-2014_06
Patent number
US08754114B2

Reaction notes

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