L-Prolinol → US10213427, Example 106

Participants

Role	Name	HCID	Charge
Reactant	L-Prolinol	HCID 640091	—
Reactant	2-(4-{3-[3-({[(2,2,2-Trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}phenyl)propanoic acid	HCID 67980157	—
Product	US10213427, Example 106	HCID 67980114	—

Reaction Steps

This compound was prepared by using procedure analogous to those described for the synthesis of Example 98, Step 9 starting from 2-(4-{3-[3-({[(2,2,2-trifluoro ethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}phenyl)propanoic acid and (2S)-pyrrolidin-2-ylmethanol. LCMS (M+H)+: m/z=567.3

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08754114B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-8cab5244157d4cac909582de1eafd12c
Source note	uspto-grants-2014_06