Stannous Chloride → HCID 53244426, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1-tert-butyl 3-ethyl 6-(4-nitrophenyl)-1H-indazole-1,3-dicarboxylate (879 mg, 2.14 mmol) in ethanol (40 Ml), was added SnCl2 (2.4 g, 10.7 mmol) and the mixture was stirred at 80° C. for 3 h. The mixture was cooled to room temperature and saturated sodium bicarbonate aqueous solution was added. The organic layer was extracted three times and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate and hexane to give ethyl 6-(4-aminophenyl)-1H-indazole-3-carboxylate (442 mg).

Provenance & Evidence