3-(Trifluoromethyl)benzoic acid → HCID 46234711, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 6-(4-aminophenyl)-1H-indazole-3-carboxylate (40 mg), 3-trifluoromethyl-benzoic acid (35.2 mg), triethylamine (40 and HOBt (25 mg) in N,N-dimethylformamide, was added EDCI (40.6 mg). The mixture was stirred at 70° C. for 12 h. The mixture cooled to room temperature and ethyl acetate and water were added. The mixture was extracted with ethyl acetate three times. The combined organic layer was washed with saturated sodium bicarbonate solution, dried over sodium sulfate, and concentrated under reduced pressure. The residue was triturated by ethylacetate/hexane to give ethyl 6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxylate (46.6 mg).

Provenance & Evidence