Hydrochloric Acid → HCID 68621686, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxylate (12 mg, 25 μmol) in THF/water/methanol (10/1/1, 2.5 Ml), was added 1N aqueous sodium hydroxide solution (1.3 Ml). The mixture was stirred at 70° C. for 12 h and cooled to room temperature. The pH of solution was adjusted to 4-5 with 1N hydrochloric acid aqueous solution. The aqueous solution was extracted with ethyl acetate and the combined organic layer was washed with water, dried over magnesium sulfated, and concentrated under reduced pressure to give 6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxylic acid (13.5 mg), which was used in next step without purification.

Provenance & Evidence