Triethylamine → HCID 68623602, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxylic acid (26 mg, 61 μmol), methyl amine hydrochloride (6.2 mg, 92 μmol), HOBt (12 mg, 92 μmol), and triethylamine (43 μl, 0.3 mmol) in N,N-dimethylformamide (0.6 Ml), was added EDCI (18 mg, 92 μmol). After the mixture was stirred at 70° C. for 12 h, the mixture was cooled to room temperature, and ethyl acetate and saturated sodium bicarbonate solution were added. The aqueous layer was extracted with ethyl acetate and the combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate/hexane to give N-methyl-6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxamide (20 mg).

Provenance & Evidence