3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 46234072, compound

Participants

Reaction Steps

To a stirred solution of ethyl 6-(3-aminophenyl)-1H-indazole-3-carboxylate (10 mg) in pyridine (1 Ml), was added 3-trifluoromethylbenzenesulfonyl chloride (6.3 μl) at room temperature. After 3 h, pyridine was removed by evaporation. Ethyl acetate and water were added and the aqueous layer was extracted with ethyl acetate three times. The combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate/hexane to give ethyl 6-(3-(3-(trifluoromethyl)phenylsulfonamido)phenyl)-1H-indazole-3-carboxylate (8.6 mg).

Provenance & Evidence