Ethyl Acetate → HCID 178521996, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 6-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-1H-indazole-3-carboxylate (73.7 mg) in tetrahydrofuran (5 Ml), was added lithium borohydride (0.44 Ml; LiBH4) at room temperature then, the mixture was stirred at 70° C. for 12 h. Saturated sodium bicarbonate solution and ethyl acetate were added. The aqueous layer was extracted with ethyl acetate and the combined organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to give 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(3-(hydroxymethyl)-1H-indazol-6-yl)phenyl)urea (32.1 mg).

Provenance & Evidence