1-BOC-3-Aminopiperidine → HCID 86670625, compound

HRID 407192Notes

Reaction equation

[C:1]([C:3]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:11]=[C:12]([C:21]([NH:23]C3CCCNC3)=[O:22])[C:13](=[O:20])[N:14]3[C:19]=2[CH:18]=[CH:17][CH:16]=[CH:15]3)[CH2:5][CH2:4]1)#[N:2].N[CH:37]1[CH2:42][CH2:41][CH2:40][N:39](C(OC(C)(C)C)=O)[CH2:38]1>>[C:1]([C:3]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:11]=[C:12]([C:21]([NH:23][CH:42]3[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]3)=[O:22])[C:13](=[O:20])[N:14]3[C:19]=2[CH:18]=[CH:17][CH:16]=[CH:15]3)[CH2:5][CH2:4]1)#[N:2]

Participants

Reactant 2

HCID 5458091-BOC-3-Aminopiperidine

HCID 53237106HCID 53237106, compound

Product 1

HCID 86670625HCID 86670625, compound

Procedure

1-[(4-Cyano-4-pyridin-2-ylpiperidin-1-yl)methyl]-4-oxo-N-piperidin-4-yl-4H-quinolizine-3-carboxamide was prepared by the procedure described for the synthesis of 1-[(4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl]-4-oxo-N-piperidin-3-yl-4H-quinolizine-3-carboxamide in Example 19, substituting tert-butyl 4-aminopiperidine-1-carboxylate for tert-butyl 3-aminopiperidine-1-carboxylate.

Sources & evidence

ORD record: ord-74b1a24359aa448090b07be775d82f06
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754220B2

Reaction notes

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