Methylamine → HCID 71150687, compound

Participants

Reaction Steps

To a solution (E)-methyl 3-chloro-6-(4-chlorophenyl)-4-(((methylsulfonyl)oxy)imino)-1,4,5,6-tetrahydropyridine-2-carboxylate (100 mg, 0.254 mmol) in DMSO (2 mL) was added 2 M methanamine in THF (0.8 mL, 1.6 mmol). The reaction mixture was stirred at ambient temp for 30 min, and then it was diluted with H2O. The product crashed out of solution, and was collect in a Buchner funnel, and dried under vacuum to yielded a brown solid (49 mg, 66%): mp 178-200° C.; 1H NMR (300 MHz, CDCl3) δ 7.88 (d, J=8.4 Hz, 1H), 7.39 (d, J=8.5 Hz, 1H), 6.95 (s, 1H), 5.39 (s, 1H), 4.07 (s, 1H), 3.98 (s, 1H), 2.98 (d, J=5.1 Hz, 1H); ESIMS m/z 292 ([M+H]+), 290 ([M−H]−).

Provenance & Evidence