Sodium hexafluorophosphate → 4-Azoniaspiro[3,4]octane hexafluorophosphate
Reaction equation
[Cl-].[CH2:2]1[N+:5]2([CH2:9][CH2:8][CH2:7][CH2:6]2)[CH2:4][CH2:3]1.[F:10][P-:11]([F:16])([F:15])([F:14])([F:13])[F:12].[Na+]>O>[F:10][P-:11]([F:16])([F:15])([F:14])([F:13])[F:12].[CH2:4]1[N+:5]2([CH2:9][CH2:8][CH2:7][CH2:6]2)[CH2:2][CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
4-Azoniaspiro[3,4]octane chloride solution in water (88 ml) was added over 10 minutes to a solution of sodium hexaflurophosphate (50.3 g) in water (100 ml), followed by a line wash of water (12 ml). Further water (50 ml) was added to aid stirring of the thick suspension. The mixture was heated to 90° C. to aid stirring. The solid was filtered and washed with water (2×100 ml) and dried in a vacuum oven to give 4-azoniaspiro[3,4]octane hexafluorophosphate (54.14 g, 70.3% of theory).
Workup
- washwash of water (12 ml)
- additionFurther water (50 ml) was added to aid
- stirringto aid stirring
- filtrationThe solid was filtered
- washwashed with water (2×100 ml)
- customdried in a vacuum oven
Sources & evidence
- ORD record
- ord-deff25f27d8247fcab196bddf385dab0
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08754240B2
Reaction notes
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