HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-4-fluorobenzothiazole-6-sulfonic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 178434671 | HCID 178434671 | — |
| Reactant | HCID 178434672 | HCID 178434672 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-4-fluorobenzothiazole-6-sulfonic acid amide | HCID 178434673 | 72% |
Reaction Steps
The title compound (280 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-4-fluorobenzothiazole-7-sulfonyl chloride, which had been derived from the chlorosulfonation of 320 mg of 4-(4-fluorobenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine, and a solution of excess ammonia dissolved in ethanol. MS (m/z, ES+): 328.0 (M+1, 100%). Yield=72%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754233B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-e154eb8d1f3a4fee8625374331b20a81 |
| Source note | uspto-grants-2014_06 |