Ammonia → HCID 178510951, compound

HRID 407342Notes

Reaction equation

HRID 407342 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[NH2:20]C1NN=C(CCCO)C=1C1SC2C=CC=CC=2N=1.N>C(O)C>[NH2:20][CH2:17][CH2:16][CH2:15][C:14]1[C:10]([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)=[C:11]([NH2:19])[NH:12][N:13]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 178509116HCID 178509116, compoundHCID 178509119HCID 178509119, compound

Product 1

HCID 178510951HCID 178510951, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound (12 mg) was prepared using 130 mg (0.39 mmol) of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine, which was derived from 3-(5-amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)-propan-1-ol, and a saturated solution of ammonia gas in ethanol. MS (m/z, ES+): 274.2 (M+1, 100%), 257.2 (M-NH2, 70%).

Sources & evidence

ORD record
ord-c3d37ce70a934db38ff0b3ab581554dd
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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